Local drug delivery system
Local drug delivery for cardiovascular applications (Nat. Biomed. Eng. 2018)
A heart is an important organ of cardiovascular system to circulate blood through the whole body. Due to dynamic mechanical motions and large cardiac output, targeting drugs to the heart is inevitably challenging. Although cardiovascular diseases, such as myocardial infarction, valvular and coronary artery diseases, seriously affect the world population, direct treatment of those diseases is performed by surgical procedures such as a sternotomy or thoracotomy, which unavoidably involve incision of the chest wall. Thus, we have developed local drug/protein delivery platform to target the heart via systemic/intramyocardial injections on a basis of intermolecular affinity of catechol/gallol moieties to biomacromolecules against shear stress in vivo.