Tissue-adhesive biomaterials have been attracted for hemostatic agents, wound closure, and other applications to multifunctional medical devices. In particular, we have developed hemostatic polymeric biomaterials for surface coating of medical tools/devices and controlling external/internal bleeding on surgical procedures. Our research scope is highly effective to solve challenging issues of delayed hemostasis from patients with chronic diseases, such as diabetes, advanced cancer, or hemophilia, patients taking aspirin and undergoing chemotherapy/cerebral surgery, and rare case patients with Ebola virus infection.